This isn't an easy recipe, but it's hands down one of the best things I've ever eaten..
http://allrecipes.com/recipe/boilerm...ailgate-chili/
This is my go-to recipe when I have leftover brisket, but I don't see why you couldn't use normal beef.
http://www.bbq-brethren.com/forum/sh...d.php?t=134996