Unless you do a side-by-side taste test, I doubt many people could tell a difference. If smoke is applied right, not oversmoked, but as part of the whole experience, very few people will notice any difference.
That said, I have never used mesquite. The majority of my smoking has been oak, hickory, and cherry,(on poultry). My son swears by peach, but I can't tell any difference in the finished product.