I don't see much difference except:
1) As already said cooking over an open fire/coals (for me usually chicken on my Santa Maria ranch grill w/ a butter, apple cider vinegar and red pepper flake mop); or,
2) When cooking whole hog I like to mop or spritz apple cider vinegar cut 50/50 with apple juice in the last hout or two to get te ACV taste. I just like the added taste, don't think it helps or hurts moisture of the final product.
Weber 26.75 OTG w/CI grates & SJ/WSM Mini
Home built 24"x72" reverse flow stick burner trailer with 18"x44" grill w/CI grates and upright SS gas oven/smoker.
Home built 48" fire pit with a 30"x30" Santa Maria style ranch grill.
Home built lump charcoal retort, iGrill & a bunch of other cooking toys.