Salt and pepper brisket is a very traditional style in Texas. Several Hill Country BBQ joints do that. Others do minor variations on that. The Salt Lick owner says his rub is equal parts salt, pepper, and cayenne.
I like simple rubs on beef and chicken -- S&P works fine on those meats, IMO. The smoke becomes the star flavor enhancer.
Like others have mentioned, a S&P rub should go on more like seasoning than a rub. You can overdo it.
It is definitely worth trying.