This is funny as I've been turning more and more to mesquite these days for smoking, not just grilling. I think it works best in big offset cookers (which I have) as yes, if it doesn't light off and turn to TBS right away you can get a funky odor. Once lit, great odor and I never get an over smoked flavor.
I find it's easy to over smoke anything with oak which is used heavily in Central Texas. I'm way out here in the great desert Southwest where mesquite is used heavily.
Horizon 24" X 48" Marshal RD Special Offset