Due to my family/work schedule, I rarely have much time to devote to bbq. I prefer to use commercially available stuff to maximize the time I'm able to find. But, while I prefer to use commercial stuff, I stick to brands like Simply Marvelous, The Rub Co., or Dizzy Pig. Made by people who actually are into bbq, vs. industrial - commercial rubs.
That being said, if you find something you like - use it. This is just what I've found works with me.
Big Steel Keg, WSM, OTG, PBC, Super Fast and Accurate Blue Splash-Proof Thermapen