Personally, I would put salt and pepper on a brisket (not really, I would add granulated garlic, onion and a tiny amount of sugar). I would not use the Pineapple Head on brisket. But, that is my taste. I think of it more as a chicken, pork, seafood rub.
I'm feeling bearish, and I'm packing a Wusthof Grand Brisket slicer from MABA
"perhaps...but then again...maybe not..."