I think that most folks are going the entire cook with a minion load. Most of the bad crap gets heated and burned out during the preheat before the meat gets on.
The issue is adding fresh KBB to a smoker that's already going. You'll get some bad smoke as the fresh KBB warms up and starts igniting.
Next time I smoke on the mini, I'll try and have a bag of Stubbs on hand, purely for refilling it during the last few hours of a smoke. KBB for the first load, since there's no worries if you let the smoker run for a while until there's sweet blue.